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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">radhyd</journal-id><journal-title-group><journal-title xml:lang="ru">Радиационная гигиена</journal-title><trans-title-group xml:lang="en"><trans-title>Radiatsionnaya Gygiena = Radiation Hygiene</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-426X</issn><issn pub-type="epub">2409-9082</issn><publisher><publisher-name>NIIRG</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21514/1998-426X-2024-17-1-25-33</article-id><article-id custom-type="elpub" pub-id-type="custom">radhyd-1013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Научные статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Scientific articles</subject></subj-group></article-categories><title-group><article-title>Оценка применимости специальной модели поведения плутония  в присутствии хелатов в случаях раневого поступления  промышленных соединений плутония работникам  ФГУП «ПО «Маяк»»</article-title><trans-title-group xml:lang="en"><trans-title>Assessing the applicability of a special model of plutonium behavior in presence of chelates  in cases of wound intake of industrial compounds of plutonium in the FSUE Mayak PA workers</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6036-4178</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколова Александра Борисовна – кандидат биологических наук, научный сотрудник</p><p>456783, Челябинская область, Озерск, Озерское шоссе, д. 19 </p></bio><bio xml:lang="en"><p>Alexandra B. Sokolova – PhD, Researcher</p><p>Ozerskoe shosse, 19, Ozersk, 456780, Chelyabinsk oblast</p></bio><email xlink:type="simple">sokolova@subi.su</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1110-6559</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ефимов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Efimov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ефимов Александр Владимирович – заведующий отделом радиационной безопасности и дозиметрии</p><p>Озерск</p></bio><bio xml:lang="en"><p>Alexander V. Efimov – Head of Department of Radiation Safety and Dosimetry</p><p> Ozersk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джунушалиев</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhunushaliev</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джунушалиев Артем Борисович – инженер-программист</p><p> Озерск</p></bio><bio xml:lang="en"><p>Artem B. Dzhunushaliev – Programmer engineer</p><p> Ozersk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский институт биофизики Федерального Медико-биологического агентства России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Southern Urals Biophysics Institute of the Federal Medical Biological Agency of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>04</month><year>2024</year></pub-date><volume>17</volume><issue>1</issue><fpage>25</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соколова А.Б., Ефимов А.В., Джунушалиев А.Б., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Соколова А.Б., Ефимов А.В., Джунушалиев А.Б.</copyright-holder><copyright-holder xml:lang="en">Sokolova A.B., Efimov A.V., Dzhunushaliev A.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.radhyg.ru/jour/article/view/1013">https://www.radhyg.ru/jour/article/view/1013</self-uri><abstract><p>В случаях поступления повышенных уровней плутония для ускорения выведения и снижения скорости отложения в органах основного депонирования используется хелат диэтилентриамин-пентауксусная кислота в форме соединения кальция Ca-ДТПА (пентацин). Для интерпретации результатов измерений нуклида в экскретах при оценке доз внутреннего облучения от плутония используются биокинетические и дозиметрические модели, рекомендуемые МКРЗ; в случае поступления актинидов через поврежденные кожные покровы рекомендуется использовать модели НКРЗ США. Так как применение хелатов существенно меняет картину выведения плутония с мочой, для описания биокинетики плутония под воздействием хелатов разрабатываются специальные модели поведения комплекса Pu-ДТПА. Целью данной работы является оценка пригодности специальной модели поведения плутония в присутствии хелатов, разработанной автором K. Konzen, для описания биокинетики плутония в организме в случаях раневого поступления промышленных соединений плутония работникам производственного объединения «Маяк». В исследовании были использованы результаты измерения активности плутония в суточном количестве мочи для 3 случаев поступления актинидов через поврежденные кожные покровы и лечением Ca-ДТПА: длительность применения препарата пентацин и сроки наблюдения за работниками зависели от уровней поступления. Для каждого случая был подобран наиболее вероятный тип поступившего соединения с помощью критерия Акаике. Затем, в те же дни, когда определялись фактические значения активности плутония в суточных количествах мочи, в соответствии с выбранной моделью были получены расчетные значения активности плутония. Для анализа соответствия расчетных данных фактически использовались статистические критерии Фостера – Стюарта, Бройша – Годфри, Манна – Уитни, Шапиро – Уилка, коэффициент детерминации. Получено, что для всех рассматриваемых случаев скорректированный коэффициент детерминации и критерий Фостера – Стюарта указывают на согласие фактических данных расчетным. Выполненный статистический анализ согласия расчетных данных фактическим результатам измерения активности плутония в моче показал, что предложенная K. Konzen специальная модель поведения плутония способна предсказывать активность плутония в моче как в период проведения мер по декорпорации радионуклидов, так и в период последействия пентацина.</p></abstract><trans-abstract xml:lang="en"><p>In cases of intake of higher levels of plutonium, a chelate diethylenetriaminepentaacetic acid is used to enhance the elimination and reduce deposition rate in the organs of major deposit in the form of calcium compound Ca-DTPA (pentacinum). To interpret the results of the nuclide measurements in excreta while estimating the doses of internal exposure to plutonium, the biokinetic and dosimetry models recommended by ICRP are applied; and in case of the actinide intake through damaged skin it is recommended to use the models of NCRP of the USA. Since the application of chelates significantly changes the picture of plutonium urinary excretion, special models of complex Pu-DTPA behavior are developed to describe the plutonium biokinetics in presence of chelates. The purpose of this work is to assess the suitability of a special model of plutonium behavior in presence of chelates elaborated by K. Konzen to describe the plutonium biokinetics in the body by the cases of wound intake of industrial plutonium compounds in the FSUE Mayak PA workers. This study used the measurements of plutonium activity in daily amount of urine for three cases with the actinide intake through damaged skin and Ca-DTPA treatment, the duration of pentacinum application and observation periods for workers depending on the levels of intake. For each case, the most likely type of an entered compound was selected using Akaike information criterion, then the daily urinary activity of plutonium was calculated by the model (estimated value) on the same days when it was determined actually (actual values). The analysis of the compliance of calculated data with actual data was conducted using the statistic tests of Foster-Stewart,Breusch-Godfrey, Mann-Whitney, Shapiro-Wilk, and the determination coefficient. It was found that for all cases considered, the adjusted determination coefficient and Foster-Stewart test indicated the compliance of actual data with calculated ones. The statistical analysis of the compliance of calculated data with actual measurements of plutonium urinary activity showed that the special model of plutonium behavior proposed by K. Konzen was able to predict the urinary activity of plutonium during both the radionuclide decorporation measures and the period of pentacinum aftereffect.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>плутоний</kwd><kwd>декорпорация</kwd><kwd>хелат</kwd><kwd>аварийное поступление</kwd><kwd>актиниды</kwd><kwd>биокинетическая модель</kwd></kwd-group><kwd-group xml:lang="en"><kwd>plutonium</kwd><kwd>decorporation</kwd><kwd>chelate</kwd><kwd>accidental intake</kwd><kwd>actinides</kwd><kwd>biokinetic model</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках Государственного контракта № 11.306.22.2 от 18.07.2022 г. по теме «Решение актуальных вопросов внутренней дозиметрии персонала и населения» (шифр «Радиометрия-22») в рамках реализации федеральной целевой программы «Обеспечение ядерной и радиационной безопасности на 2016–2020 годы и на период до 2030 года».</funding-statement><funding-statement xml:lang="en">The work was carried out within the framework of the  State Contract No. 11.306.22.2 as of 18.07.2022 entitled  “Solution of the topical issues of internal dosimetry of  personnel and population” (code “Radiometry-22”) within  the implementation of federal target program “Nuclear safety  and radiation protection for 2016-2020 and for the period till  2030”.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">ICRP. 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