radhydРадиационная гигиенаRadiatsionnaya Gygiena = Radiation Hygiene1998-426X2409-9082NIIRG10.21514/1998-426X-2024-17-4-55-67radhyd-1090Research ArticleОБЗОРЫREVIEWSПолиморфизм гена hOGG1 и предрасположенность к злокачественным новообразованиям у людей, подвергшихся длительному облучению с низкой мощностью дозыPolymorphism of hOGG1 gene and susceptibility to malignant neoplasms in people affected by long-term low dose rate exposurehttps://orcid.org/0000-0002-2649-5123ЯнишевскаяМ. А.YanishevskayaM. A.

Янишевская Мария Александровна – младший научный сотрудник лаборатории молекулярно-клеточной радиобиологии.

454076, Челябинск, ул. Воровского, 68-А

Mariya A. Yanishevskaya – Junior Researcher, Laboratory of Molecular and Cellular Radiobiology, Urals Research Center for Radiation Medicine, Federal Medical Biological Agency.

Vorovsky str., 68a, Chelyabinsk, 454076

yanishevskaya@urcrm.ruhttps://orcid.org/0000-0002-2567-7945БлиноваЕ. А.BlinovaE. A.

Блинова Евгения Андреевна – кандидат биологических наук, заведующая лабораторией молекулярно-клеточной радиобиологии УНПЦ РМ ФМБА России; доцент кафедры радиационной биологии ЧелГУ.

Челябинск

Evgenia A. Blinova – Candidate of Biological Sciences, Head of the Laboratory of Molecular Cellular Radiobiology, Urals Research Center for Radiation Medicine, Federal Medical Biological Agency; Assoc. Prof. of the Department of Radiation Biology of the Chelyabinsk State University.

Chelyabinsk

https://orcid.org/0000-0003-4464-0889ШишкинаЕ. А.ShishkinaE. A.

Шишкина Елена Анатольевна – доктор биологических наук, заведующая биофизической лабораторией УНПЦ РМ ФМБА России; доцент кафедры радиационной биологии ЧелГУ.

Челябинск

Elena A. Shishkina – Doctor of Biological Sciences, Senior Researcher of the Biophysics laboratory, Urals Research Center for Radiation Medicine, Federal Medical Biological Agency, Assoc. Prof. of the Department of Radiation Biology of the Chelyabinsk State University.

Chelyabinsk

https://orcid.org/0000-0003-2583-5808АклеевА. В.AkleyevA. V.

Аклеев Александр Васильевич – доктор медицинских наук, профессор, заслуженный деятель науки РФ, директор УНПЦ РМ ФМБА России; заведующий кафедрой радиационной биологии ЧелГУ.

Челябинск

Alexander V. Akleyev – Doctor of Medical Sciences, Professor, Honoured Science Worker of the Russian Federation, Director of the Urals Research Center for Radiation Medicine, Federal Medical Biological Agency; Head of the Department of Radiation Biology of the Chelyabinsk State University.

Chelyabinsk

Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства РоссииРоссияUrals research Center for Radiation Medicine, Federal Medical-Biological AgencyRussian FederationУральский научно-практический центр радиационной медицины Федерального медико-биологического агентства России; Челябинский государственный университетРоссияUrals research Center for Radiation Medicine, Federal Medical-Biological Agency; Chelyabinsk State UniversityRussian Federation2024150120251745567Copyright © Янишевская М.А., Блинова Е.А., Шишкина Е.А., Аклеев А.В., 20252025Янишевская М.А., Блинова Е.А., Шишкина Е.А., Аклеев А.В.Yanishevskaya M.A., Blinova E.A., Shishkina E.A., Akleyev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.radhyg.ru/jour/article/view/1090

В проведенном раннее исследовании [1] мы показали повышенный риск развития злокачественных новообразований у носителей минорного аллеля rs1052133*G гена hOGG1, подвергшихся хроническому низкоинтенсивному радиационному воздействию на реке Тече (Южный Урал) в широком диапазоне доз (максимально до 3507 мГр на красный костный мозг) в результате деятельности производственного объединения «Маяк» в 1950-х годах. Целью настоящего исследования являлась оценка вклада радиационного фактора в риск развития злокачественных новообразований у лиц, подвергшихся хроническому облучению на реке Тече. Для этого нами был проведен анализ фонового уровня генетически обусловленного риска в генеральной популяции необлученных людей на основе мета-анализа данных мировой литературы, посвященных поиску ассоциации rs1052133 гена hOGG1 с риском развития злокачественных новообразований. На последнем этапе результаты мета-анализа сопоставлены с данными по облученным людям. В результате исследования установлено, что необлученные и облученные носители аллеля rs1052133*G имели сопоставимый повышенный риск развития злокачественных новообразований, отношение шансов 1,20; 95% доверительный интервал [1,06–1,35], p=0,01 и отношение шансов 1,38; 95% доверительный интервал [1,05–1,83], p=0,023 соответственно.

In the previous study [1], we showed an increased risk of malignant neoplasms in carriers of the minor allele rs1052133*G of the hOGG1 gene who were affected by chronic radiation exposure at a wide range of doses (up to 3,507 mGy to the red bone marrow) at the Techa River (Southern Urals) contaminated due to the activities of the Mayak Production Association in the 1950s. The objective of the present study was to assess the contribution of radiation factor to the risk of malignant neoplasms development in persons chronically exposed at the Techa River. For this purpose, we analyzed the background level of genetically determined risk in the general population of unexposed people on the basis of meta-analysis of the world literature data on the search for the association of rs1052133 of the hOGG1 gene with the risk of malignant neoplasms development. At the final stage, the results of the meta-analysis were compared with data on exposed people. The study found that unexposed and exposed carriers of the rs1052133*G allele had a comparable increased risk of developing malignant neoplasms, odds ratio 1.20; 95% confidence interval [1.06–1.35], p=0.01 and odds ratio =1.38; 95% confidence interval [1.05–1.83], p=0.023, respectively.

мета-анализфоновый уровеньгенетически обусловленный рискполиморфизмhOGG1rs1052133Ser326Cysзлокачественные новообразованияионизирующее излучениеТечаЮжный Уралmeta-analysisbackground levelgenetically determined riskpolymorphismshOGG1rs1052133Ser326Cysmalignant neoplasmsionizing radiationthe Techa RiverSouthern UralsАвторы выражают благодарность анонимным рецензентам за проделанную работу. Финансирование работы осуществлялось в рамках федеральной целевой программы «Обеспечение ядерной и радиационной безопасности на 2016-2020 годы и на период до 2030 года».The authors are grateful to anonymous reviewers for their work. The work was carried out with the financial support of the Federal Medical and Biological Agency of Russia, within the framework of the Federal target program “Ensuring nuclear and radiation safety for 2016-2020 and for the period up to 2030”.ReferencesЯнишевская М.А., Блинова Е.А., Кореченкова А.В., Аклеев А.В. 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The authors declare that there are no conflicts of interest present.