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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">radhyd</journal-id><journal-title-group><journal-title xml:lang="ru">Радиационная гигиена</journal-title><trans-title-group xml:lang="en"><trans-title>Radiatsionnaya Gygiena = Radiation Hygiene</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-426X</issn><issn pub-type="epub">2409-9082</issn><publisher><publisher-name>NIIRG</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21514/1998-426X-2026-19-3-21-28</article-id><article-id custom-type="elpub" pub-id-type="custom">radhyd-1386</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Научные статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Scientific articles</subject></subj-group></article-categories><title-group><article-title>Оценка доз в красном костном мозге при пероральном поступлении 89Sr</article-title><trans-title-group xml:lang="en"><trans-title>Red bone marrow dose assessment due to oral intake of 89Sr</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1457-4916</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарагин</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharagin</surname><given-names>P. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шарагин Павел Алексеевич, магистр биологических наук, научный сотрудник лаборатории цифровых и вычислительных методов дозиметрии; Ассистент кафедры радиобиологии</p><p>454014, Россия, г. Челябинск, ул. Воровского, 68-А</p><p>РИНЦ Author ID: 1044931</p></bio><bio xml:lang="en"><p>Pavel A. Sharagin Master of Biology, Researcher of the R&amp;D Laboratory of Digital and Computational Dosimetry Methods; Assistant of the Department of Radiobiology</p><p>68A, Vorovsky Str., Chelyabinsk, 454141</p><p>RSCI Author ID: 1044931</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4958-3214</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толстых</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolstykh</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Толстых Евгения Игоревна доктор биологических наук, заведующая лабораторией цифровых и вычислительных методов дозиметрии, ведущий научный сотрудник</p><p>Челябинск</p><p>РИНЦ Author ID: 119291</p></bio><bio xml:lang="en"><p>Evgenia I. Tolstykh Doctor of Biological Sciences, Head of the R&amp;D Laboratory of Digital and Computational Dosimetry Methods</p><p>Chelyabinsk</p><p>RSCI Author ID: 119291</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4464-0889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шишкина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shishkina</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шишкина Елена Анатольевна доктор биологических наук, директор научно-исследовательского института радиологической защиты в составе; ведущий научный сотрудник, доцент кафедры радиобиологии</p><p>Челябинск</p><p>РИНЦ Author ID: 94748</p></bio><bio xml:lang="en"><p>Elena A. Shishkina Doctor of Biological Sciences, Director at the Research Institute of Radiological Protection; Associate Professor of the Department of Radiobiology</p><p>Chelyabinsk</p><p>RSCI Author ID: 94748</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский Федеральный научно-клинический центр медицинской биофизики Федерального медико-биологического агентства; Челябинский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Southern Urals Federal Research and Clinical Center for Medical Biophysics, Federal Medical Biological Agency; Chelyabinsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Южно-Уральский Федеральный научно-клинический центр медицинской биофизики Федерального медико-биологического агентства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Southern Urals Federal Research and Clinical Center for Medical Biophysics, Federal Medical Biological Agency</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>18</day><month>10</month><year>2026</year></pub-date><volume>19</volume><issue>3</issue><fpage>21</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарагин П.А., Толстых Е.И., Шишкина Е.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Шарагин П.А., Толстых Е.И., Шишкина Е.А.</copyright-holder><copyright-holder xml:lang="en">Sharagin P.А., Tolstykh E.I., Shishkina E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.radhyg.ru/jour/article/view/1386">https://www.radhyg.ru/jour/article/view/1386</self-uri><abstract><p>Остеотропный 89Sr попадал в организм жителей прибрежных территорий реки Течи, что приводило к его накоплению в костной ткани и облучению красного костного мозга. Цель исследования расчет дозовых коэффициентов, позволяющих перейти от перорального поступления 89Sr к поглощенной накопленной дозе на красный костный мозг для взрослых мужчин и женщин. Материалы и методы: Для оценки концентрации изотопа в ткани-источнике использовали биокинетическую модель Sr-AG. После чего оценивали мощности поглощенных доз в ткани-мишени, c помощью дозиметрических фантомов, имитирующих геометрию сред, в которых моделируется перенос излучений. Результатом этого были коэффициенты перехода от удельной активности 89Sr в трабекулярной и кортикальной кости к мощности поглощенной дозы в красном костном мозге. Фантомы выполнены по оригинальной методике, их параметры основаны на опубликованных результатах измерений характеристик скелета. Возмущение этих параметров позволяет имитировать индивидуальную изменчивость морфологии кости для расчёта неопределенности. Результаты исследования и их обсуждение: В результате были получены коэффициенты перехода: от стронция в трабекулярной кости 2,3 и 2,2 ( × 10-7 Гр/с на Бк/кг) для мужчин и женщин соответственно; от стронция в кортикальной кости 0,74 и 0,78 ( × 10-7 Гр/с на Бк/кг) для мужчин и женщин соответственно. Оценённые дозовые коэффициенты находятся в диапазоне 1,84,4 (× 10-9 Гр/Бк) для мужчин и 2,30–5,55 (× 10-9 Гр/Бк) для женщин. Относительные стандартные неопределенности дозовых коэффициентов не превышали 40 %. Заключение: Значения, рассчитанные в рамках данной работы, могут быть использованы для реконструкции доз с целью улучшения оценки радиогенных рисков для облучённого населения Уральского региона, а также рисков, связанных с применением таких радиофармпрепаратов как хлорид 89Sr.</p></abstract><trans-abstract xml:lang="en"><p>Bone-seeking[<xref ref-type="bibr" rid="cit89">89</xref>] Sr ingested to the body of Techa river residents and accumulated in bone tissue. It’s led to active red bone marrow exposure. The aim of this study: to calculate the dose coefficients converting activity from oral intake to the cumulative absorbed dose in red bone marrow for adult men and women. Materials and Methods: The Sr-AG biokinetic model was used to estimate the isotope concentration in the source tissue. After that, the absorbed dose rates in the target tissue were evaluated using dosimetric phantoms described the geometry of media in which radiation transfer is simulated. The result of this modeling is the dose factors converting the specific activity of[<xref ref-type="bibr" rid="cit89">89</xref>] Sr in bone to the absorbed dose rate in red bone marrow. The phantoms are made according to the original method of stochastic parametric skeleton dosimetry modeling. Their parameters are based on a large number of published measurement results of the characteristics of skeletal bones. The perturbation of these parameters makes it possible to simulate the individual variability of bone morphology to calculate the corresponding uncertainties. Results and Discussion: The dose factors for strontium incorporated in the trabecular bone was 2.33 × 10[-7] and 2.23 × 10[ -7] G/s per Bq/kg for male and female respectively. For the cortical bone dose factors were 0.74 and 0.78 ( × 10[ -7] G/s per Bq/kg) for male and female, respectively. The estimated dose coefficients range from 1.81-4.38 ( × 10[ -9] Gy/Bq) for male and 2.30-5.55 ( × 10[ -9] Gy/Bq) for female. The relative standard dose coefficients uncertainties did not exceed 40 %. Conclusion: The values calculated in the framework of this work can be used to reconstruct doses in order to improve radiogenic risk assessments for the exposed population of the Ural region, as well as the risks associated with the use of radiopharmaceuticals such as strontium chloride.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>красный костный мозг</kwd><kwd>дозиметрическое моделирование</kwd><kwd>89Sr</kwd><kwd>дозовые коэффициенты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>red bone marrow</kwd><kwd>dosimetric modelling</kwd><kwd>[89] Sr</kwd><kwd>dose coefficients</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках гранта Российского научного фонда по мероприятию «Проведение фундаментальных научных исследований и поисковых научных исследований малыми отдельными научными группами» (региональный конкурс) Соглашение № 25-25-20092 поддерживаемого Регионом программа Челябинской области «Развитие науки в Челябинской области», грант в форме субсидии Соглашение № 30-2025-003346.</funding-statement><funding-statement xml:lang="en">The work was carried out within the framework of a grant from the Russian Science Foundation for the event "Conducting basic scientific research and exploratory scientific research by small individual scientific groups" (regional competition) Agreement No. 25-25-20092 supported by the Region Chelyabinsk Region program "Development of Science in the Chelyabinsk Region", grant in the form of a subsidy Agreement No. 30-2025-003346.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дёгтева М.О., Шагина Н.Б., Воробьёва М.И. и др. 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