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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">radhyd</journal-id><journal-title-group><journal-title xml:lang="ru">Радиационная гигиена</journal-title><trans-title-group xml:lang="en"><trans-title>Radiatsionnaya Gygiena = Radiation Hygiene</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-426X</issn><issn pub-type="epub">2409-9082</issn><publisher><publisher-name>NIIRG</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21514/1998-426X-2021-14-3-41-55</article-id><article-id custom-type="elpub" pub-id-type="custom">radhyd-817</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Научные статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Scientific articles</subject></subj-group></article-categories><title-group><article-title>Прогностическая оценка риска рака легкого при сочетанном действии радона и курения с использованием аддитивно-мультипликативной модели риска</article-title><trans-title-group xml:lang="en"><trans-title>Prognostic assessment of lung cancer risk under combined action of radon and smoking using an additive-multiplicative risk model</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жуковский</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukovsky</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Михаил Владимирович Жуковский, доктор технических наук, профессор, директор, главный научный сотрудник</p><p>Екатеринбург</p></bio><bio xml:lang="en"><p>Mikhail V. Zhukovsky, Doctor of Technical Sciences, Professor, Director, Head Researcher</p><p>Ekaterinburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ярмошенко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yarmoshenko</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Илья Владимирович Ярмошенко, кандидат физико-математических наук, ведущий научный сотрудник, заместитель</p><p>Екатеринбург</p></bio><bio xml:lang="en"><p>Ilya V. Yarmoshenko, Candidate of Physical and Mathem atical Sciences, Senior Researcher, Deputy Director</p><p>Ekaterinburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Онищенко</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Onishchenko</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александра Дмитриевна Онищенко, кандидат биологических наук, старший научный сотрудник</p><p>Екатеринбург</p></bio><bio xml:lang="en"><p>Aleksandra D. Onishchenko, Candidate of Biological Sciences, Researcher</p><p>Ekaterinburg</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малиновский</surname><given-names>Г. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Malinovsky</surname><given-names>G. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Георгий Петрович Малиновский,  кандидат биологических наук, старший научный сотрудник</p><p>620990, Екатеринбург, ул. Софьи Ковалевской, д. 20</p></bio><bio xml:lang="en"><p>Georgy P. Malinovsky, Candidate of Biological Sciences, Researcher</p><p>Sofia Kovalevskaya str., 20, Ekaterinburg, 620990 </p></bio><email xlink:type="simple">georgy@ecko.uran.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт промышленной экологии Уральского отделения Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Industrial Ecology, Ural Branch of the Russian Academy of  Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2021</year></pub-date><volume>14</volume><issue>3</issue><fpage>41</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жуковский М.В., Ярмошенко И.В., Онищенко А.Д., Малиновский Г.П., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Жуковский М.В., Ярмошенко И.В., Онищенко А.Д., Малиновский Г.П.</copyright-holder><copyright-holder xml:lang="en">Zhukovsky M.V., Yarmoshenko I.V., Onishchenko A.D., Malinovsky G.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.radhyg.ru/jour/article/view/817">https://www.radhyg.ru/jour/article/view/817</self-uri><abstract><p>В работе обосновано применение геометрической смешанной аддитивно-мультипликативной модели для моделирования риска возникновения рака легкого при сочетанном действии радона и курения. Использование геометрической смешанной модели позволяет: 1) снизить расхождения в оценках риска рака легкого для мужчин и женщин, 2) прогнозировать риск при изменении распространенности курения и изменении среднего уровня объемной активности радона. С применением геометрической смешанной модели проведен расчет рисков возникновения рака легкого для населения Российской Федерации при изменении процентного распределения курящих среди населения, увеличения ожидаемой средней продолжительности жизни и изменения среднего уровня объемной активности радона в жилых зданиях. В предположении, что среднее значение объемной активности радона в России в настоящее время округленно, с учетом всех типов зданий, составляет 50 Бк/м3, вклад радона в общую смертность в 2009 г. составлял 0,46% и 0,20% для мужчин и женщин соответственно. Моделирование показало, что эффект снижения заболеваемости раком легкого вследствие прогнозируемого снижения доли курящего населения отчасти будет нивелироваться ростом числа случаев реализации риска рака легкого при увеличении ожидаемой продолжительности жизни. Для гипотетической ситуации, когда все население ведет здоровый образ жизни, смертность от сердечно-сосудистых, онкологических, инфекционных заболеваний, заболеваний респираторного тракта и от внешних причин значительно снизилась, вклад радона в общую смертность вырастет до примерно 0,8%. В случае, если за счет широкого применения энергоэффективных технологий в строительстве средний уровень содержания радона в зданиях повысится, вклад радона в общую смертность будет еще более ощутим.</p></abstract><trans-abstract xml:lang="en"><p>An application of geometric mixed additive-multiplicative models for lung cancer risk modeling under combined action of radon and smoking is justified in this paper. The geometric mixed model allows: 1) to reduce the discrepancies between estimates of the lung cancer risk for males and females, 2) to predict the population risk under condition of the varying smoking prevalence and changing average indoor radon concentration level. Using the geometric mixed model, the calculation of the lung cancer risks for the Russian Federation population was carried out for different percentages of smokers among the population, an increase in life expectancy, and a change in the average radon concentration level in residential buildings. Assuming that currently rounded average indoor radon concentration in Russia is 50 Bq/m3, the contribution of radon to total mortality in 2009 was 0.46% and 0.20% for male and female, respectively. Modeling has shown that the effect of lung cancer mortality reducing due to the predicted decrease in the proportion of smoking population will partly be offset by an increase in the realization of lung cancer risk with the life expectancy increase. For a hypothetical situation, when the entire population maintain a healthy lifestyle and mortality from cardiovascular, oncological, infectious diseases, diseases of the respiratory tract and from external causes has significantly decreased, the contribution of radon exposure to total mortality will increase to about 0.8%. If the average level of radon in buildings will increase due to energy-efficient technologies widespread implementation in building construction, the contribution of radon to total mortality will be even more noticeable. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>радон</kwd><kwd>курение</kwd><kwd>рак легкого</kwd><kwd>риск</kwd><kwd>модель</kwd><kwd>прогноз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>radon</kwd><kwd>smoking</kwd><kwd>lung cancer</kwd><kwd>risk</kwd><kwd>model</kwd><kwd>prognosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">National Research Council. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: The National Academies Press; 2006. 422 pp.</mixed-citation><mixed-citation xml:lang="en">National Research Council. 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