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Radiation safety problems during the patient traveling by public transport after radiopharmaceutical therapy with 131I

https://doi.org/10.21514/1998-426X-2023-17-2-97-108

Abstract

Radiopharmaceutical therapy with 131I has been one of the most common types of radiopharmaceutical therapy  for  many  years.  Radiation  safety  of  the  public  is  ensured  by  limiting  the  patient  contacts  until  the radiological parameters are reduced to the established criteria. To increase the availability of the radiopharmaceutical therapy with 131I, softer patient release criteria for 131I have been proposed. However, early patient release may increase exposure to the public, e.g. in transport. The aim of the work is to evaluate the radiation exposure  from  patients  with 131I -MIBG  and  Na131I on  the  public  in  transport  considering  the  generation  of biological waste. In this work, 131I excretion from the body of patients in transport was evaluated for different scenarios of patient travel to the place of residence. As a result, it was found that mitigation of patient release criteria leads to an increase in the effective dose to the public in transport and an increase in the 131I activity excreted with patient waste. The specific activity in the tanks of biotoilets in transport, generated after the pas -sage of a patient with injected 131I -labeled radiopharmaceuticals, exceeds the limit value of classifying liquid waste as radioactive. To optimize radiation protection of the public, it is advisable to apply a differentiated approach to release patients after therapy with 131I: to group non-resident patients into a separate category retaining for them the established release criterion (without mitigation) to minimize the radiation impact on the public.

About the Authors

A. V. Petryakova
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal  Service for Surveillance on Consumer Rights Protection and  Human Wellbeing; The City Hospital No 40 of the Kurortny District
Russian Federation

 Anastasia  V.  Petryakova  –  junior  researcher; radiation safety engineer

Mira Str., 8, Saint-Petersburg, 197101



L. A. Chipiga
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal  Service for Surveillance on Consumer Rights Protection and  Human Wellbeing; A.Granov  Russian  Scientific   Center   of   Radiology  and  Surgical  Technologies  of  the Ministry of  Health of   the Russian Federation; Almazov  National  Medical  Research Centre of the Ministry of Health of the Russian  Federation
Russian Federation

Larisa A. Chipiga –  Ph.D., research fellow; research fellow; docent

Saint-Petersburg



I. A. Zvonova
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal  Service for Surveillance on Consumer Rights Protection and  Human Wellbeing
Russian Federation

Irina A. Zvonova – Doctor of Technical Sciences, Chief Researcher of Protection Laboratory

Saint-Petersburg



A. V. Vodovatov
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal  Service for Surveillance on Consumer Rights Protection and  Human Wellbeing; Saint-Petersburg State Pediatric Medical University
Russian Federation

Aleksandr  V.  Vodovatov   –  Ph.D., Head of Laboratory; docent

Saint-Petersburg



G. A. Gorsky
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal  Service for Surveillance on Consumer Rights Protection and  Human Wellbeing; I. Mechnikov North Western State Medical University
Russian Federation

Grigory  A.  Gorsky  –  Ph.D.,  Deputy  Director  of  the Innovation  work; docent 

Saint-Petersburg



A. A. Stanzhevsky
A.Granov  Russian  Scientific   Center   of   Radiology  and Surgical  Technologies  of   the Ministry of Health  of  the   Russian Federation
Russian Federation

Andrey  A.  Stanzhevsky  –  M.D.,  Deputy  Director  for Research

Saint-Petersburg



References

1. Evaluation of Medical Exposure to Ionizing Radiation. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2020/2021 Report Volume I. Annex A.

2. Zvonova IA, Likhtarev IA, Nikolaeva AA. Thyroid irradiation accompanying radioiodine examination of patients with thyroid diseases. Meditsinskaya Radiologiya = Medical radiology. 1984;4:42-44. (In Russian).

3. Carrasquillo JA, Chen CC. Neuroendocrine Tumors: Therapy with 131I-MIBG. In: Strauss H, Mariani G, Volterrani D, Larson S. (eds). Nuclear Oncology. Springer: Cham; 2016. P. 1-38. https://doi.org/10.1007/978-3-319-26067-9_26-1.

4. Chipiga LA, Ladanova ER, Vodovatov AV, Zvonova IA, Mosunov AA, Naurzbaeva LT, et al. Trends in the development of nuclear medicine in the Russian Federation for 2015–2020. Radiatsionnaya Gygiena = Radiation Hygiene . 2022;15(4): 122-133. (In Russian) https://doi.org/10.21514/1998-426X-2022-15-4-122-133.

5. Chipiga LA, Zvonova IA, Vodovatov AV, Petryakova AV, Stanzhevsky AA, Vazhenina DA, et al. Improvement of the approach to definition of patient release criteria after radionuclide therapy. Radiatsionnaya Gygiena = Radiation Hygiene. 2023;16(2): 19-31. (In Russian).

6. Balonov MI, Golikov VYu, Zvonova IA. Radiological criteria for patient release from clinic after radionuclide therapy of brachytherapy with sealed source implantation. Radiatsionnaya Gygiena = Radiation Hygiene . 2009;2(4): 5-9. (In Russian).

7. Zvonova I, Balonov M, Golikov V. Release criteria for patients having undergone radionuclide therapy and criteria for their crossing the state border of the Russian Federation. Radiation Protection Dosimetry . 2011;147(1-2): 254-257. doi: 10.1093/rpd/ncr308.

8. International Atomic Energy Agency, Release of Patients After Radionuclide Therapy, Safety Reports Series No. 63. IAEA, Vienna; 2009.

9. International Atomic Energy Agency. Radiation protection and safety of radiation sources: international basic safety standards. Interim edition. Safety Standards Series No. GSR Part 3 (interim). IAEA, Vienna; 2011.

10. International Commission on Radiological Protection. Release of patients after therapy with unsealed radionuclides. ICRP Publication 94. Annual ICRP . 2004;34(2).

11. Jacobsson L, Mattsson S, Johansson L, Lindberg S, Fjglling M. Biokinetics and dosimetry of ‘3’I-metaiodobenzylguanidine (MIBG). Proc. Fourth ht. Rndiophnrmuceutical Dosimetry Symposium. Oak Ridge 1985, Oak Ridge Assoc. Universities CONF-851113, Oak Ridge National Laboratories. Oak Ridge, Tennessee; 1986. P. 389-398.

12. Lishmanova YuB, Chernov VI (Eds.) Radionuclide diagnostics for practitioners. Tomsk: STT; 2004. P. 317-319. (In Russian).

13. Willegaignon J, Crema KP, Oliveira NC, Pelissoni RA, Coura-Filho GB, Sapienza MT, et al. Pediatric 131I-MIBG Therapy for Neuroblastoma: Whole-Body 131I-MIBG Clearance, Radiation Doses to Patients, Family Caregivers, Medical Staff, and Radiation Safety Measures. Clinival Nuclear Medicine. 2018;43(8): 572-578. doi: 10.1097/RLU.0000000000002158.

14. O’Doherty MJ, Kettle AG, Eustance CN, Mountford PJ, Coakley AJ. Radiation dose rates from adult patients receiving 131I therapy for thyrotoxicosis. Nuclear Medicine Community. 1993;14(3): 160-8. doi: 10.1097/00006231-199303000-00003.

15. Barrington SF, Kettle AG, O’Doherty MJ, Wells CP, Somer EJR, Coakley AJ. Radiation dose rates from patients receiving iodine-131 therapy for carcinoma of the thyroid. European Journal of Nuclear Medicicne. 1996;23: 123–130 doi: 10.1007/BF01731834.

16. International Commission on Radiological Protection. Conversion Coefficients for Radiological Protection Quantities for External Radiation Exposures. ICRP Publication 116. Annual ICRP . 2010;40(2-5).

17. ICRP. Radiation Dose to Patients from Radiopharmaceuticals. ICRP Publication 53. Annals of the ICRP. 1988;18(1-4).

18. Chipiga LA, Vodovatov AV, Zvonova IA, Stanzhevsky AA, Petryakova AV, Anokina EE, et al. Management of biological waste of patients after radionuclide therapy. Radiatsionnaya Gygiena = Radiation Hygiene . 2022;15(2): 19-30. (In Russian) https://doi.org/10.21514/1998-426X-2022-15-2-19-30.

19. Gromov AV, Akhmatdinov RR, Biblin AM, Tutelyan OE. Comparative analysis of information on radiation accidents in the Russian Federation in 2010–2022. Radiatsionnaya Gygiena = Radiation Hygiene. 2023;16(4): 122-133. (In Russian) https://doi.org/10.21514/1998-426X-2023-16-4-122-133.


Review

For citations:


Petryakova A.V., Chipiga L.A., Zvonova I.A., Vodovatov A.V., Gorsky G.A., Stanzhevsky A.A. Radiation safety problems during the patient traveling by public transport after radiopharmaceutical therapy with 131I. Radiatsionnaya Gygiena = Radiation Hygiene. 2024;17(2):97-108. (In Russ.) https://doi.org/10.21514/1998-426X-2023-17-2-97-108

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ISSN 1998-426X (Print)
ISSN 2409-9082 (Online)