Полиморфизм гена hOGG1 и предрасположенность к злокачественным новообразованиям у людей, подвергшихся длительному облучению с низкой мощностью дозы

В проведенном раннее исследовании [1] мы показали повышенный риск развития злокачественных новообразований у носителей минорного аллеля rs1052133*G гена hOGG1, подвергшихся хроническому низкоинтенсивному радиационному воздействию на реке Тече (Южный Урал) в широком диапазоне доз (максимально до 3507 мГр на красный костный мозг) в результате деятельности производственного объединения «Маяк» в 1950-х годах. Целью настоящего исследования являлась оценка вклада радиационного фактора в риск развития злокачественных новообразований у лиц, подвергшихся хроническому облучению на реке Тече. Для этого нами был проведен анализ фонового уровня генетически обусловленного риска в генеральной популяции необлученных людей на основе мета-анализа данных мировой литературы, посвященных поиску ассоциации rs1052133 гена hOGG1 с риском развития злокачественных новообразований. На последнем этапе результаты мета-анализа сопоставлены с данными по облученным людям. В результате исследования установлено, что необлученные и облученные носители аллеля rs1052133*G имели сопоставимый повышенный риск развития злокачественных новообразований, отношение шансов 1,20; 95% доверительный интервал [1,06–1,35], p=0,01 и отношение шансов 1,38; 95% доверительный интервал [1,05–1,83], p=0,023 соответственно.

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