Computer program for calculation of in-utero doses from anthropogenic radionuclides
https://doi.org/10.21514/1998-426X-2025-18-1-121-126
Abstract
Introduction: A computer program was created to calculate intrauterine radiation doses, "FetusDose", in the frame of the dosimetric support of epidemiological studies conducted for the population of the Ural region.
Summary: The paper presents the method and describes the principle of organization and functionality of the computer program. The software is designed to calculate trimester and total doses accumulated in the active marrow and extra-skeletal tissues of the fetus when it is irradiated with anthropogenic radionuclides that have accidentally contaminated the environment. When calculating doses, two radiation scenarios are considered: the external one from soil contaminated with gamma-emitters (95Zr, 95Nb, 144Ce/144Pr/144mPr, 106Ru/106Rh, 91Y and 137Cs/137mBa) and the internal one from oral intake of radionuclides (90Sr/90Y, 89Sr, 137Cs/137mBa and 144Ce/144Pr/144mPr) into the mother's body with food and water.
Conclusion: The software can be used both to study the consequences of radiation incidents that have already occurred, and to predict the radiation exposure from potential threats. The program will also be useful for educational purposes in the training of specialists in the field of radiobiology and dosimetry.
Keywords
Supporting agencies: The study was supported by Federal Medical-Biological Agency in the framework of Russian Federal Targeted Program “Provision of nuclear and radiation safety for the period 2016– 2020 and for the period up to 2035” R & D
About the Authors
E. A. Shishkina
Urals Research Center for Radiation Medicine, Federal Medical Biological Agency; Chelyabinsk State University
Russian Federation
Russian Federation
Elena A. Shishkina, Doctor of Biological Sciences, Acting Head of the Laboratory, Associate Professor
Biophysics Laboratory; Department of Radiobiology
454141; Vorovsky Str., 68A; Chelyabinsk
P. A. Sharagin
Urals Research Center for Radiation Medicine, Federal Medical Biological Agency
Russian Federation
Russian Federation
Pavel A. Sharagin, Junior Researcher
Biophysics Laboratory
Chelyabinsk
E. I. Tolstykh
Urals Research Center for Radiation Medicine, Federal Medical Biological Agency
Russian Federation
Russian Federation
Evgenia I. Tolstykh, Doctor of Biological Sciences, Leading Researcher
Biophysics Laboratory
Chelyabinsk
References
1. Shaw P, Duncan A, Vouyouka A, Ozsvath K. Radiation Exposure and Pregnancy. Journal of Vascular Surgery. 2011;53(1): 28–34. DOI: 10.1016/j.jvs.2010.05.140.
2. Preston D, Cullings H, Suyama A, et al. Solid Cancer Incidence in Atomic Bomb Survivors Exposed In Utero or as Young Children. JNCI: Journal of the National Cancer Institute. 2008;100(6): 428–436. DOI: 10.1093/jnci/djn045.
3. McCollough CH, Schueler BA, Atwell TD, Braun NN, Regner DM, Brown DL, et al. Radiation exposure and pregnancy: when should we be concerned? Radiographics. 2007;27(4): 909-917; discussion P. 917–918.
4. Akleyev A, Deltour I, Krestinina L, et al. Incidence and Mortality of Solid Cancers in People Exposed in Utero to Ionizing Radiation: Pooled Analyses of Two Cohorts from the Southern Urals, Russia. PLoS ONE. 2016;11(8): e0160372. DOI: 10.1371/journal.pone.0160372.
5. Krestinina LYu, Kharyuzov YE, Epiphanova SB, et al. Cancer Incidence after in Utero Exposure to Ionizing Radiation in Techa River Residents. Radiation Research. 2017;188(3): 314–324. DOI: 10.1667/RR14695.1.
6. Shishkina EA, Volchkova AYu, Degteva MO, Napier BA. Evaluation of dose rates in the air at non-uniform vertical distribution of gamma-emitting radionuclides in different types of soil. Voprosy radiatsionnoy bezopasnosti = Radiation Safety Problems. 2016;3.: 43−52 (In Russian).
7. Shishkina EA, Volchkova AYu, Degteva MO, Napier BA. Dose coefficients to convert air kerma into organ dose rate values for people of different ages externally exposed to <sup>137</sup>Cs in soil. Voprosy radiatsionnoy bezopasnosti = Radiation Safety Problems. 2018;3: 36−47 (In Russian).
8. Petoussi-Henss N, Satoh D, Schlattl H, Zankl M, Spielmann V. Organ doses of the fetus from external environmental exposures. Radiation Environmental Biophysics. 2021;60(1): 93-113. DOI: 10.1007/s00411-020-00891-6.
9. Maynard MR, Shagina NB, Tolstykh EI, Degteva MO, Fell TP, Bolch WE. Fetal organ dosimetry for the Techa River and Ozyorsk Offspring Cohorts, part 2: radionuclide S values for fetal self-dose and maternal cross-dose. Radiation and Environmental Biophysics. 2015;54(1): 47–59. DOI: 10.1007/s00411-014-0570-5.
10. The Metabolism of Plutonium and Related Elements. ICRP Publication 48. Annals of the ICRP. 1986;16(2-3).
11. Doses to the Embryo and Fetus from Intakes of Radionuclides by the Mother. ICRP Publication 88. Annals of the ICRP. 2001;31(1–3).
12. Shagina NB, Tolstykh EI, Degteva MO, Anspaugh LR, Napier BA. Age and gender specific biokinetic model for strontium in humans. Journal of Radiological Protection. 2015;35(1): 87–127.
13. Shagina NB, Fell TP, Tolstykh EI, Harrison JD, Degteva MO. Strontium biokinetic model for the pregnant woman and fetus: application to Techa River studies. Journal of Radiological Protection. 2015;35(3): 659–676. DOI: 10.1088/0952-4746/35/3/659.
14. Maynard MR, Shagina NB, Tolstykh EI, Degteva MO, Fell TP, Bolch WE. Fetal organ dosimetry for the Techa River and Ozyorsk Offspring Cohorts, part 2: radionuclide S values for fetal self-dose and maternal cross-dose. Radiation and Environmental Biophysics. 2015;54(1): 47-59. DOI: 10.1007/s00411-014-0570-5.
15. Degteva M.O., Tolstykh E.I., Shishkina E.A., et. al. Stochastic Parametric Skeletal Dosimetry model for humans: General description. PLoS ONE. 2021. Vol. 16, № 10 P. e0257605. DOI: 10.1371/journal.pone.0257605
16. Sharagin PA, Shishkina EA, Tolstykh EI, Degteva MO. The effect of detailing the trabecular structure of bone phantoms on the assessment of the bone marrow dose from <sup>89,90</sup>Sr. Radiatsionnaya Gygiena = Radiation Hygiene. 2022;15(4): 7-14. (In Russian) DOI: 10.21514/1998-426X-2022-15-4-7-14.
Review
For citations:
Shishkina E.A., Sharagin P.A., Tolstykh E.I. Computer program for calculation of in-utero doses from anthropogenic radionuclides. Radiatsionnaya Gygiena = Radiation Hygiene. 2025;18(1):121-126. (In Russ.) https://doi.org/10.21514/1998-426X-2025-18-1-121-126
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