Comparative analysis of radiogenic risk of ischemic heart disease and cerebrovascular diseases in the cohort of workers chronically exposed to radiation
https://doi.org/10.21514/1998-426X-2025-18-4-58-69
Abstract
Circulatory diseases are the leading cause of death all around the world. Even a small increase in radiogenic risk would lead to a significant increase in incident cases and deaths as the number of individuals exposed to radiation for different purposes increases constantly. The aim of the study was a comparative analysis of radiogenic risk of incidence and mortality from ischemic heart disease and cerebrovascular diseases in the cohort of Mayak Production Association workers based on several dosimetry systems. The first analysis of studied incident cases and death causes was performed using dosimetry system “Doses-2005” which included data on occupational histories as well as external and internal radiation exposure doses for workers employed at one of the main facilities during 1948–1972. The subsequent dosimetry systems, “MWDS-2008” and “MWDS-2013”, additionally included data for workers employed in the later years (1973–1982). The necessity to improve the external dose estimates was conditioned by a number of factors, i.e. using different types of dosimeters during all monitoring period, lack of accounting for individual radiation exposure specificities for separate workers etc.; whereas discrepancies between plutonium activities in some organs/tissues estimated by the systems and the ones measured in autopsy samples made for improvements in internal dosimetry system. Conclusion: The excess relative risk estimate for ischemic heart disease incidence and mortality was the most significantly affected by the improvements in dosimetry system for the internal exposure due to incorporated plutonium.
Keywords
ischemic heart disease,
cerebrovascular diseases,
radiogenic risk,
dosimetry system,
Mayak workers cohort
Supporting agencies: The study was carried out within the framework of the state contract as of 6 June 2024 №11.313.24.2 with Federal medical biological agency titled “Assessment of chronic radiation exposure effects and study of their pathogenesis for improvement of medical provision for personal and population exposed to radiation”.
About the Authors
M. B. Moseeva
Southern Urals Federal Research and Clinical Center for Medical Biophysics of the Federal Medical-Biological Agency
Russian Federation
Russian Federation
Maria B. Moseeva – Researcher
19 Ozyorskoe Shosse, Ozyorsk, Chelyabinsk Region, 456783
T. V. Azizova
Southern Urals Federal Research and Clinical Center for Medical Biophysics of the Federal Medical Biological Agency
Russian Federation
Russian Federation
Tamara V. Azizova – Head of the Research Department of Radiation Epidemiology, Senior Researcher
Ozyorsk
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Review
For citations:
Moseeva M.B., Azizova T.V. Comparative analysis of radiogenic risk of ischemic heart disease and cerebrovascular diseases in the cohort of workers chronically exposed to radiation. Radiatsionnaya Gygiena = Radiation Hygiene. 2025;18(4):58-69. (In Russ.) https://doi.org/10.21514/1998-426X-2025-18-4-58-69
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