Preliminary assessment of 225Ac excretion in patients undergoing radionuclide therapy with 225Ac-DOTA-TATE
L. A. Chipiga,
A. V. Vodovatov,
A. A. Mosunov,
K. A. Saprykin,
A. V. Gromov,
S. K. Vasiliev,
A. V. Petryakova,
D. A. Vazhenina,
M. V. Odintsova,
V. B. Nomokonova,
A. A. Stanzhevsky,
D. N. Maystrenko https://doi.org/10.21514/1998-426X-2023-16-3-46-55
Abstract
The aim of this study was to evaluate the activity of 225Ac in urine of patients undergoing radionuclide therapy with 225Ac-DOTA-TATE. Activity concentration was determined in the urine samples collected within 72 hours after injection of 225Ac-DOTA-TATE, using the ORTEC semiconductor gamma spectrometer, model TSP-DX-100T-PAC-PKG-1. Calculation of excreted activities was additionally performed based on scintig- raphy scans of patients receiving 225Ac-DOTA-TATE. Scans were conducted 5 times for each patient: immedi- ately after injection, at 4 hours, and on the 1st, 2nd, and 3rd days after injection of the radiopharmaceutical. Absolute activity values and fractions of the injected activity were calculated based on the specific activity values. The results of the calculated activity concentration values demonstrate that maximum excretion was observed within the four hours after 225Ac-DOTA-TATE injection. Significant differences between the two methods of determining 225Ac activity were observed only on the third day after radiopharmaceutical injection, which allows for the simplification of future experimental work by using indirect radioactivity measurement methods for activity calculations. There were no significant differences between patient groups with different number of 225Ac-DOTA-TATE injection, which allows for the exclusion of this parameter in the evaluation of experimental results. The results of this study represent the first published experimental data on the determi- nation of actinium excretion in patients.
About the Authors
L. A. Chipiga
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation; Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ph.D., research fellow, Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; research fellow, A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation; docent, Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation
Mira str., 8, Saint-Petersburg, 197101
A. V. Vodovatov
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Saint-Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Ph.D., Head of Laboratory, Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; docent, Saint-Petersburg State Pediatric Medical University
A. A. Mosunov
Peter the Great St. Petersburg Polytechnic University
Russian Federation
Russian Federation
student in Peter the Great St. Petersburg Polytechnic University
K. A. Saprykin
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Russian Federation
Russian Federation
Senior Researcher Head of the Laboratory for Dosimetry of Natural Sources Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
A. V. Gromov
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Senior Researcher, head of emergency response laboratory Saint-Petersburg
Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
S. K. Vasiliev
1Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Leading Researcher Radium Institute named after V.G. Khlopin JOINT-STOCK COMPANY
Russian Federation
Russian Federation
Leading Engineer-researcher of external exposure laboratory Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Ph.D. Leading Researcher Radium Institute named after V.G. Khlopin JOINT-STOCK COMPANY
A. V. Petryakova
Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; The City Hospital No 40 of the Kurortny District
Russian Federation
Russian Federation
acting junior researcher, Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev, Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; radiation safety engineer, Saint-Petersburg City Hospital No. 40
D. A. Vazhenina
A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci (Med.), Radiologist Laboratory of Isotope Research Methods, Chief Researcher A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
M. V. Odintsova
A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Cand. of Sci. (Med.), Head of radiotherapy department №1 (day hospital) with the radionuclide therapy group Russian Scientific Center for A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
V. B. Nomokonova
A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
oncologist of the radiotherapy department №1 (day hospital) with the radionuclide therapy group A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
A. A. Stanzhevsky
A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci (Med.), Deputy Director for Research, A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
D. N. Maystrenko
A. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dr. of Sci (Med.), Head of A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies of the Ministry of Health of the Russian Federation
References
1. Wambersie A. ICRU report 62, prescribing, recording and reporting photon beam therapy (supplement to ICRU Report 50). ICRU News, 1999.
2. Maystrenko DN, Stanzhevsky AA, Vazhenina DA, Odintsova MV, Popov SA, Nomokonova VB, et al. Radioligand therapy with drugs based on radionuclide 225Aс: experience of A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies. Luchevaya diagnostika i terapiya = Diagnostic radiology and radiotherapy. 2022;13(4): 86-94. (In Russian) https://doi.org/10.22328/2079-5343-2022-13-4-86-94.
3. Rubira L, Deshayes E, Santoro L, Kotzki PO. 225Ac-Labeled Somatostatin Analogs in the Management of Neuroendocrine Tumors: From Radiochemistry to Clinic. Pharmaceutics. 202 3;15(4):1051.
4. Occupational Intakes of Radionuclides: Part 4. ICRP Publication 141.Annals of the ICRP. 2019. 48(2-3).
5. Occupational Intakes of Radionuclides: part 3. ICRP publication 137. Annals of the ICRP. 2017. 46(3-4).
6. Chipiga LA, Vodovatov AV, Petryakova AV, Zvonova IA, Stanzhevsky AA, Maistrenko DN, et al. Justification of differential approach to management of patient biological waste in nuclear medicine departments. Radiatsionnaya Gygiena = Radiation Hygiene. 2022;15(4): 34-44. (In Russian) https://doi.org/10.21514/1998-426X-2022-15-4-34-44.
7. Chipiga LA, Vodovatov AV, Zvonova IA, Stanzhevsky AA, Petryakova AV, Anokina EE, et al. Management of biological waste of patients after radionuclide therapy. Radiatsionnaya Gygiena = Radiation Hygiene. 2022;15(2): 19-30. (In Russian) https://doi.org/10.21514/1998-426X-2022-15-2-19-30.
8. Petrova AE, Chipiga LA, Vodovatov AV, Stanzhevsky AA, Maystrenko DN, Lumpov AA, et al. Estimation of absorbed doses in patients’ organs from the released radionuclide-label during radionuclide therapy with 225Ac. Radiatsionnaya Gygiena = Radiation Hygiene. 2022;15(1): 120-131. (In Russian) https://doi.org/10.21514/1998-426X-2022-15-1-120-131.
9. Benabdallah N, Scheve W, Dunn N, Silvestros D, Schelker P, Abou D, et al. Practical considerations for quantitative clinical SPECT/CT imaging of alpha particle emitting radioisotopes. Theranostics. 2021;11(20):9721.
10. Lopatkin NA. Urology: National Guide. Short edition. Moscow: GEOTAR-Media; 2013. 608 p.
11. Kurth J, Krause BJ, Schwarzenböck SM, Stegger L. External radiation exposure, excretion, and effective half-life in 177LuPSMA-targeted therapies. EJNMMI research. 2018;8:1-11.
12. Chipiga LA, Zvonova IA, Vodovatov AV, Petryakova AV, Stanzhevsky AA, Vazhenina DA, et al. Improvement of the approach to definition of patient release criteria after radionuclide therapy. Radiatsionnaya Gygiena = Radiation Hygiene. 2023;16(2): 19-31. (In Russian) https://doi.org/10.21514/1998-426X-2023-16-2-19-31.
13. Wehrmann C, Stefan S, Zachert C, Müller D. Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOC. Cancer biotherapy & radiopharmaceuticals. 2007;22(3): 406-416.
14. Levart D, Kalogianni E, Corcoran B, Mulholland N. Radiation precautions for inpatient and outpatient 177Lu-DOTATATE peptide receptor radionuclide therapy of neuroendocrine tumours. EJNMMI physics. 2019;6(1): 1-12.
Review
For citations:
Chipiga L.A., Vodovatov A.V., Mosunov A.A., Saprykin K.A., Gromov A.V., Vasiliev S.K., Petryakova A.V., Vazhenina D.A., Odintsova M.V., Nomokonova V.B., Stanzhevsky A.A., Maystrenko D.N. Preliminary assessment of 225Ac excretion in patients undergoing radionuclide therapy with 225Ac-DOTA-TATE. Radiatsionnaya Gygiena = Radiation Hygiene. 2023;16(3):46-55. (In Russ.) https://doi.org/10.21514/1998-426X-2023-16-3-46-55
Views:
558
Email this article 