Malignant neoplasms of the central nervous system of the PA Mayak personnel

The objective is to study the incidence of malignant tumors of the central nervous system of the personnel of the Mayak production association. Material and Methods: The study used data from the medical and dosimetric personnel register of the “Mayak” production association personnel hired in 1948-2016 and the cancer population register of the city of Ozyorsk. An assessment of the standardized ratio of morbidity rates among the city's population and the staff of the Mayak production association was carried out. Results and Discussion: During the follow-up period from 1948 to 2017, 220 cases of malignant neoplasms of the central nervous system were registered in the city of Ozyorsk, of which 70 cases were among the Mayak production association workers included in the medical dosimetric register (57 cases among male staff, 13 among female employees). Malignant brain tumors prevailed in the structure of the studied lesions (87.1 %), the most common lesions affected several areas of the brain (28.5 %) and the temporal lobe (14.3 %). No cases of malignant tumors of the central nervous system were recorded among male staff until 1960, and until 1980 among female staff. The age-standardized ratio of the incidence of malignant tumors of the central nervous system among the staff of Mayak and the population of Ozyorsk in men was 1.00 (95 % CI: 0.76; 1.29), in women – 0.91 (95 % CI: 0.48; 1.56). The estimates obtained turned out to be statistically indistinguishable from the unit, which indicates that there are no differences in the incidence rates of the population of Ozyorsk as a whole and the staff of the Mayak production association as a part of it. Conclusion: The results of the study confirm the previously obtained data on the absence of the influence of the occupational radiation factor on the incidence of malignant neoplasms of the central nervous system of the population of the city of Ozyorsk, including the staff of Mayak production association.

1. Merabishvili VM. The state of oncological care in Russia: epidemiology and survival of patients with malignant neoplasms (one-year and five-year) for all tumor localizations. Impact of the coronavirus pandemic (population study). Zlokachestvennye opukholi = Malignant tumors. 2023;13(3s1): 85-96. (In Russian). DOI: 10.18027/2224-5057-2023-13-3s1-85-96.

2. Malignant neoplasms in Russia in 2015 (Morbidity and mortality). Eds. Kaprin AD, Starinsky VV, Petrova GV. Moscow: P.A. Herzen Moscow Oncology Research Institute - branch of the Federal State Budgetary Institution "NMIRC" of the Ministry of Health of the Russian Federation; 2017. 250 p. (In Russian).

3. Amirian ES, Ostrom QT, Liu Y, Barnholtz-Sloan J, Bondy ML. Nervous system. In: Thun M., ed. Cancer epidemiology and prevention. 4th ed. Online edition. New York: Oxford Academic; 2017. DOI: 10.1093/oso/9780190238667.003.0056.

4. Karlsson P, Holmberg E, Lundell M, Mattsson A, Holm LE, Wallgren A. Intracranial tumors after exposure to ionizing radiation during infancy: a pooled analysis of two Swedish cohorts of 28,008 infants with skin hemangioma. Radiation Research. 1998;150(3): 357-364.

5. Sadetzki S, Chetrit A, Freedman L, Stovall M, Modan B, Novikov I. Long-term follow-up for brain tumor development after childhood exposure to ionizing radiation for tinea capitis. Radiation Research. 2005;163(4): 424-432. DOI: 10.1667/rr3329.

6. Preston DL, Ron E, Yonehara S, Kobuke T, Fujii H, Kishikawa M, et al. Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure. Journal of the National Cancer Institute. 2002;94(20): 1555-1563. DOI: 10.1093/jnci/94.20.1555.

7. Shintani T, Hayakawa N, Hoshi M, Sumida M, Kurisu K, Oki S, et al. High incidence of meningioma among Hiroshima atomic bomb survivors. Radiation Research. 1999;40(1): 49-57. DOI: 10.1269/jrr.40.49.

8. Brenner AV, Sugiyama H, Preston DL, Sakata R, French B, Sadakane A, et al. Radiation risk of central nervous system tumors in the Life Span Study of atomic bomb survivors, 1958—2009. European Journal of Epidemiology. 2020;35(6): 591-600. DOI: 10.1007/s10654-019-00599-y.

9. Denisova EV, Kuznetsova IS, Sokolnikov ME. Incidence of malignant neoplasms of the central nervous system in Ozersk. Onkologiya. Zhurnal imeni P.A. Gertsena = Oncology. Journal named after P.A. Herzen. 2023;6(12): 43-49. (In Russian). DOI: 10.17116/onkolog20231206143.

10. Sokolnikov ME, Kabirova NR, Okatenko PV, Koshurnikova NA, Tsareva YuV, Martinenko IA, et al. Medical and dosimetric register of personnel of the Mayak production association: status and prospects. Voprosy radiatsionnoy bezopasnosti = Radiation Safety Issues. 2023;3(111): 42-55. (In Russian).

11. Drozhko EG, Khokhryakov VV. Irradiation of residents of the city of Chelyabinsk-65 associated with emissions into the atmosphere of 131I. Radiatsiya i risk = Radiation and Risk. 1995;5: 159–162. (In Russian).

12. Dos Santos Silva I. Cancer epidemiology: principles and methods. Lyon: International. Agency for Research on Cancer; 1999. 442 p.

13. Breslow NE, Day NE. Statistical Methods in Cancer Research. Volume II – The Design and Analysis of Cohort Studies. IARC Scientific Publications № 82, International Agency for Research on Cancer, Lyon; 120-162.

14. Braganza MZ, Kitahara CM, Berrington de González A, Inskip PD, Johnson KJ, Rajaraman P. Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review. Journal of Neuro-Oncology. 2012;14(11): 1316-24. DOI: 10.1093/neuonc/nos208.

15. Hunter N, Kuznetsova IS, Labutina EV, Harrison JD. Solid cancer incidence other than lung, liver and bone in Mayak workers: 1948-2004. British Journal of Cancer. 2013;109(7): 1989-1996. DOI: 10.1038/bjc.2013.543.

16. Sokolnikov ME, Koshurnikova NA, Yurkin AM, Martinenko IA, Denisova EV, Tsareva YuV, et al. Incidence of solid cancers (excluding lung, liver, and skeletal cancers) in a cohort of workers at the Mayak Production Association, 1948–2017 Voprosy radiatsionnoy bezopasnosti = Radiation Safety Issues. 2021;3(103): 56–71. (In Russian).

17. Moseeva MB, Azizova TV, Bannikova MV. Morbidity and mortality from tumors of the central nervous system in a cohort of workers exposed to chronic radiation. Meditsinskaya radiologiya i radiatsionnaya bezopasnost = Medical Radiology and Radiation Safety. 2022;67(4): 42–48. (In Russian). DOI: 10.33266/1024-6177-2022-67-4-42-48.

18. Muirhead CR, O’Hagan JA, Haylock RG, Phillipson MA, Willcock T, Berridge GL, et al. Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers. British Journal of Cancer. 2009;100: 206-212. DOI: 10.1038/sj.bjc.6604825.

19. Ivanov VK, Gorskiy AI, Tsyb AF, Ivanov SI, Naumenko RN, Ivanova SI. Solid cancer incidence among the Chernobyl emergency workers residing in Russia: estimation of radiation risks. Radiation and Environmental Biophysics. 2004;43(1): 35–42. DOI: 10.1007/s00411-003-0223-6.

20. Dyachenko AA, Subbotina AV, Izmailov TR, Gluhareva NA, Krasilnikov AV, Grzhibovskij AM, et al. Primary malignant neoplasms of the central nervous system in the Arkhangelsk region: structure and dynamics of epidemiological indicators in 2000-2011. Vestnik Rossijskogo nauchnogo centra rentgenoradiologii = Bulletin of the Russian Scientific Center of Roentgenology and Radiology. 2013;13(1): 1-27. (In Russian).

21. Merabishvili VM, Dyachenko AA, Valkov MYu, Krasilnikov AV. Epidemiology of malignant neoplasms of the brain and other parts of the central nervous system in the Northwestern Federal District of Russia. Voprosy onkologii=Issues of Oncology. 2014;60(1): 32-40. (In Russian).