PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE
Abstract
In experiments on rats (290 animals ) exposed to chronic γ-radiation in the total dose of 10.0 Gy it was detected that prescription of synthetic pharmaceutical of the dihydropyridine class-glutapyrone-together with drinking water during 6 months reduced the rate of malignant neoplasms from 26,5% in the control group to 13% in the treated animals. In radiation-exposed rats that received glutapyrone there was a narrowing of spectrum of the emerged neoplasms (connectively-tissual tumors only) as compared to the animals of the radiated control group, where blastomas of epithelium and lymphoid origin were also revealed. Low toxicity of glutapyrone and its anticarcinogenic action show the possibility of practical application of preparation for prevention radiation carcinogenesis.
About the Authors
L. P. Vartanyan
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Tel.: (812)596-85-43
Russian Federation
Tel.: (812)596-85-43
E. V. Ivanov
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Russian Federation
A. B. Marcochev
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Russian Federation
E. A. Bisenieks
Latvian Institute of Organic Synthesis, Riga
Latvia
Latvia
S. F. Vershinina
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Russian Federation
G. F. Gornaeva
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Russian Federation
Yu. I. Pustovalov
Russian Research Centre for Radiology and Surgical Technologies, Saint-Petersburg
Russian Federation
Russian Federation
T. V. Ponomareva
Federal Scientific Organization «Saint-Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev», Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Vartanyan L.P., Ivanov E.V., Marcochev A.B., Bisenieks E.A., Vershinina S.F., Gornaeva G.F., Pustovalov Yu.I., Ponomareva T.V. PREVENTION OF RADIATION CARCINOGENESIS IN RATS BY MEANS OF OXYPYRIDINE DERIVATIVE – GLUTAPYRONE. Radiatsionnaya Gygiena = Radiation Hygiene. 2012;5(2):5-8. (In Russ.)
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