FACTORS AFFECTING THE FREQUENCY OF RADIATION REACTIONS IN CANCER PATIENTS OF THE TECHA RIVER COHORT AND EURT
Abstract
For revealing the main factors determining the frequency of radiation reactions and radiation complications in cancer patients previously exposed to chronic accidental exposure associated with the activity of the plant «Mayak», the data from medical records of 89 patients, treated with external beam radiotherapy from 1995 to 2011, and had reference to chronic radiation exposure history are analyzed. The assessment of peripheral blood, the nature and severity of radiation reactions and complications was performed. Statistical processing of the data revealed that the factors determining the frequency and severity of radiation reactions did not differ in features in cancer patients with chronic radiation exposure history. The value of absorbed dose has no significant effect on the frequency of radiation reactions.
About the Authors
E. Ya. Mozerova
Chelyabinsk Regional Clinical Oncological Centre, Chelyabinsk
Russian Federation
e-mail: katerina_mozerov@mail.ru
Russian Federation
e-mail: katerina_mozerov@mail.ru
G. A. Veremeeva
Ural Scientifical and Practice Center of Radiation Medicine, Chelyabinsk
Russian Federation
Russian Federation
T. M. Sharabura
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
References
1. Крестинина, Л.Ю. Онкологическая смертность при хроническом воздействии «малых» и «средних» доз облучения в когорте лиц, облученных на ВУРС / Л.Ю. Крестинина, А.В. Аклеев // Бюллетень сибирской медицины. – 2005. – № 2. – C. 36–45.
2. Медико-биологические и экологические последствия радиоактивного загрязнения реки Теча / под ред. А.В. Аклеева, М.Ф. Киселева. – М. : Медбиоэкстрем, 2001. – 531 с.
3. Бардычев, М.С. Местные лучевые повреждения / М.С. Бардычев, А.Ф. Цыб. – М. : Медицина, 1985. – 240 с.
4. Радиационная медицина : руководство для врачей-ис- следователей и организаторов здравоохранения. Т. II. Радиационные поражения человека / В.М. Абдуллаева [и др.] ; под ред. А.К. Гуськовой и Г.Д. Селидовкина ; под общей редакцией Л.А. Ильина. – М. ИздАТ, 2001. – 432 с.
5. Akleyev, A.V. Early hematopoietic effects of chronic radiation exposure in humans / A.V. Akleyev [et al.] // Health Phys. – 2010. – V. 99, № 3. – P. 330–336.
6. Akleyev, A.V. Adaptive Capacities of Lymphocytes in Techa Riverside Residents Chronically Exposed to Radiation / A.V. Akleyev [et al.] // Jpn. J. Health Phys. – 2004. – V. 39, № 4. – P. 375–381.
7. Akleyev, A.V. Dynamics of Blood Cell Composition in Residents of the Techa Riverside Villages / A.V. Akleyev, T.A. Varfolomeyeva // Acta Med Nagasaki. – 2007. – № 52. – P. 19–28.
8. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. National Cancer Institute. 2009.
9. Degteva, M.O. Dose Reconstruction System for the Exposed Population Living Along the Techa River / M.O. Degteva [et al.]
10. ICRP Publication 103. Pergamon Press, Oxford, UK, 2007.
11. Krestinina, L.Yu. Protracted Radiation Exposure and Cancer Mortality in the Techa River Cohort / L.Yu. Krestinina // Radiation Research. – 2005. – V. 164. – P. 602–611.
12. Krestinina, L.Yu. Solid cancer incidence and low-dose-rate radiation exposures in the Techa River cohort: 1956–2002 / L.Yu. Krestinina // Int. J. Epidemiol. – 2007. – V. 36, № 5. – P. 1038–1046.
Review
For citations:
Mozerova E.Ya., Veremeeva G.A., Sharabura T.M. FACTORS AFFECTING THE FREQUENCY OF RADIATION REACTIONS IN CANCER PATIENTS OF THE TECHA RIVER COHORT AND EURT. Radiatsionnaya Gygiena = Radiation Hygiene. 2012;5(3):34-37. (In Russ.)
Views:
722
Email this article 