Radon, smoking and human papilloma virus as risk factors for lung cancer in an environmental epidemiological study
https://doi.org/10.21514/1998-426X-2017-10-2-106-114
Abstract
The aim of the study: to analyze the risk of lung cancer caused by exposure to indoor radon using an environmental study, taking into account recent data on the possible effect of Human Papillomavirus, based on lung cancer mortality and radon exposure in the Russian regions.
Materials and methods: in the analysis, linear dependencies of lung cancer against influencing factors were used. The average radon concentration for the regions of Russia was earlier reconstructed on the basis of the annual reports of the form 4-DOZ.
Information on morbidity and mortality from malignant neoplasms in Russia was obtained from annual reports issued by the Р. Hertsen Moscow Oncology Research Institute. As a surrogate of the level of infection with Human Papillomavirus, the incidence of cervix cancer was used. The smoking prevalence was estimated applying data on the incidence of tongue cancer.
Results: taking into account smoking and infection with
Human Papillomavirus, it is possible to obtain estimates of lung cancer excess relative risk when induced by radon in dwellings consistent with the results of case-control studies.
Conclusion: the analysis of regionally aggregated data on deaths from lung cancer in Russia, the average level of indoor radon concentrations
and significant risk factors for lung cancer confirms the linear threshold-free concept of radiation-induced carcinogenesis.
About the Authors
G. P. Malinovsky
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Georgy P. Malinovsky –Candidate of biological Science
Address for correspondence: Sofia Kovalevskaya str., 20, Ekaterinburg, 620219; E-mail: georgy@ecko.uran.ru
I. V. Yarmoshenko
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences
Russian Federation
Ilya V. Yarmoshenko – Candidate of Physical and Mathematical Sciences, Deputy Director, Senior Researcher
Russian Federation
Ilya V. Yarmoshenko – Candidate of Physical and Mathematical Sciences, Deputy Director, Senior Researcher
M. V. Zhukovsky
Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences,
Russian Federation
Mikhail V. Zhukovsky – Doctor of Technical Science, Professor, Director, Chief Researcher
Russian Federation
Mikhail V. Zhukovsky – Doctor of Technical Science, Professor, Director, Chief Researcher
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Review
For citations:
Malinovsky G.P., Yarmoshenko I.V., Zhukovsky M.V. Radon, smoking and human papilloma virus as risk factors for lung cancer in an environmental epidemiological study. Radiatsionnaya Gygiena = Radiation Hygiene. 2017;10(2):106-114. (In Russ.) https://doi.org/10.21514/1998-426X-2017-10-2-106-114
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